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Veterinary medicine knowledge application of florfenicol in the treatment of various bacterial diseases in poultry

阅读:641   时间:2022-04-22 08:33

  Florfenicol is also known as fluoromethylsulfonomycin and fluprofen. It is a broad-spectrum antibiotic specially used for amide alcohols. Monofluoro derivatives formed by fluorination of thiamphenicol are very soluble in dimethylformamide, methanol and water. Therefore, through in-depth research and analysis of flufenicol bulk drug and improvement of production process, Huizhong veterinary medicine has developed a new high water-soluble process of automatic dissolution in water, flufenicol powder puldekang.

  Function and use

  Florfenicol has the advantages of broad spectrum, high efficiency, low toxicity, excellent absorption, wide distribution in the body and no aplastic anemia. It is effective against most Gram-negative bacteria, Gram-positive bacteria, some mycoplasmas and some strains resistant to chloramphenicol, thiamphenicol, oxytetracycline, sulfonamide or ampicillin, and its antibacterial activity is better than chloramphenicol and Thiamphenicol. In vitro bacteriostatic test showed that the product could inhibit bacteria at low concentration and slowly sterilize at high concentration; Its MBC value to most bacteria is equal to MIC value or 2 ~ 4 times of MIC value, and all have different degrees of post antibiotic effect.

  Florfenicol is absorbed rapidly and widely distributed in the body. The drug concentration in the liver and kidney is higher than that in the blood; The concentration in lung, heart, spleen, pancreas and intestine was equivalent to that in blood; The blood drug concentration in cerebrospinal fluid is low, only 1 / 4 ~ 1 / 2 of the blood drug concentration. This indicates that this product is suitable for treating systemic infectious diseases.

  Product features

  1. Florfenicol is a broad-spectrum and efficient antibiotic specially used for animals with low toxicity.

  2. Oral administration has excellent absorption, wide distribution in the body and no aplastic anemia.

  3. Strong antibacterial activity, bacteriostasis at low concentration and slow sterilization at high concentration.

  4. It is suitable for treating systemic infectious diseases.

  Product advantages

  1. High purity levoflofenicol raw material has no residue of chloramphenicol and thiamphenicol, strong antibacterial activity, high safety, low toxic and side effects and low drug resistance.

  2. New supramolecular inclusion technology is adopted to avoid the interaction between florfenicol and special excipients, increase the solubility and dissolution of florfenicol, adjust the release rate, perfectly solve the problem of water solubility, easy dissolution, no precipitation, no blocking of drinking water system and less possible loss.

  3. It has stable chemical properties, improves the bioavailability of drugs, reduces the toxic and side effects of drugs, and has a definite effect in clinical application.

  clinical application

  This product is widely used in the treatment of various bacterial diseases of poultry, such as avian Escherichia coli, avian cholera, chicken dysentery, chronic respiratory diseases, Duck infectious serositis, etc; Prevention and treatment of bacteria and chronic respiratory diseases in secondary infection of avian influenza, infectious bronchitis, infectious laryngotracheitis, avian paramyxovirus and other viral diseases or mixed infection of virus, bacteria and mycoplasma.

  Usage and dosage

  According to the effective ingredients, mixed feeding: 200 ~ 300 birds per 1000 kg feed ɡ (i.e. 100 per bag) ɡ Mix 133 ~ 200kg), mix well and feed for 3 ~ 5 days; Mixed drinking: 100 ~ 200mg per liter of water (i.e. 100 per bag) ɡ Add water (200 ~ 400 kg), concentrate the dosage for 4 ~ 5 hours, and use it for 3 ~ 5 days; Halve prevention.

  Clinical application examples

  1. Treat a series of clinical symptoms and pathological changes caused by single or mixed infection of avian colibacillosis, avian cholera, Riemerella anatipestifer and other bacterial diseases.

  Florfenicol powder (400 kg of water / bag) + doxycycline hydrochloride soluble powder (10 ~ 20 kg of water per gram of active ingredient)

  2. Treat the secondary or mixed infection of digestive system infection and bacterial disease caused by chicken dysentery and viral diseases.

  Florfenicol powder (400kg water / bag) + Qiqing Baidu granule (200kg water / bag)

  3. It is mainly used to solve respiratory syndrome caused by single or mixed infection of conventional bacteria and viruses.

  Morning: florfenicol powder (400kg water / bag); Afternoon: Maxing Shigan oral liquid (250ml per bottle, 200kg water)

  Precautions for clinical application

  1. It is forbidden for laying hens during laying period.

  2. Animals with severe immune deficiency during vaccination or immune function are prohibited.

  3. Animals with renal insufficiency need to appropriately reduce or prolong the interval of administration.

  4. This product has certain immunosuppressive effect when it is higher than the recommended dose.

  5. The rest period is 20 days for pigs, 5 days for chickens and 375 degrees for fish.


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